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1.
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8 p, 1.3 MB |
Longitudinal study on nerve ultrasound and corneal confocal microscopy in NF155 paranodopathy
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Athanasopoulos, D. (Ruhr-University) ;
Motte, J. (Ruhr-University) ;
Fisse, A.L. (Ruhr-University) ;
Grueter, T. (Ruhr-University) ;
Trampe, N. (Katholische Kliniken Emscher-Lippe) ;
Sturm, D. (Ruhr University) ;
Tegenthoff, M. (Ruhr University) ;
Sgodzai, M. (Ruhr-University) ;
Klimas, R. (Ruhr-University) ;
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Gold, R. (Ruhr-University) ;
Pitarokoili, K. (Ruhr-University) ;
Universitat Autònoma de Barcelona
We report the case of a 27-year-old patient with subacute anti-neurofascin-155 neuropathy with bifacial palsy, who showed excellent response to rituximab. We provide longitudinal data of established clinical scores, nerve conduction studies, antibody titers, and novel imaging methods (nerve ultrasonography and corneal confocal microscopy). [...]
2020 -  10.1002/acn3.51061
Annals of Clinical and Translational Neurology, Vol. 7 Núm. 6 (january 2020) , p. 1061-1068
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2.
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14 p, 1.4 MB |
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
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Calls, Aina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Torres Espín, Abel (University of California San Francisco) ;
Tormo, Marc (Universitat Pompeu Fabra) ;
Martínez-Escardó, Laura (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Bonet, Núria (Universitat Pompeu Fabra) ;
Casals, Ferran (Universitat de Barcelona) ;
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Yuste Mateos, Víctor J. (Víctor José) (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Udina i Bonet, Esther (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Bruna, Jordi (Universitat Autònoma de Barcelona. Institut de Neurociències)
Peripheral neuropathy is a relevant dose-limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy. [...]
2022 - 10.1002/acn3.51691
Annals of Clinical and Translational Neurology, Vol. 9, Num. 12 (November 2022) , p. 1985-1998
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10 p, 924.1 KB |
Real-world evaluation of ocrelizumab in multiple sclerosis : A systematic review
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Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Matthews, Paul M. (UK Dementia Research Institute Centre at Imperial College London) ;
Simpson, Alex (F. Hoffmann-La Roche) ;
Petrie, John L. (PHMR Ltd) ;
Sammon, Cormac (PHMR Ltd) ;
Ramagopalan, Sreeram (F. Hoffmann-La Roche) ;
Disanto, Giulio (Ente Ospedaliero Cantonale) ;
Kuhle, Jens (University of Basel) ;
Universitat Autònoma de Barcelona
Across its clinical development program, ocrelizumab demonstrated efficacy in improving clinical outcomes in multiple sclerosis, including annualized relapse rates and confirmed disability progression. [...]
2023 - 10.1002/acn3.51732
Annals of Clinical and Translational Neurology, Vol. 10 Núm. 3 (march 2023) , p. 302-311
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4.
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15 p, 1.7 MB |
Preliminary validity of the Draw a Shape Test for upper extremity assessment in multiple sclerosis
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Graves, Jennifer S. (University of California San Diego) ;
Ganzetti, Marco (F. Hoffmann-La Roche Ltd, Basel) ;
Dondelinger, Frank (F. Hoffmann-La Roche Ltd, Basel) ;
Lipsmeier, Florian (F. Hoffmann-La Roche Ltd, Basel) ;
Belachew, Shibeshih (F. Hoffmann-La Roche Ltd, Basel) ;
Bernasconi, Corrado (F. Hoffmann-La Roche Ltd, Basel) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Beek, Johan van (F. Hoffmann-La Roche Ltd, Basel) ;
Baker, Michael (F. Hoffmann-La Roche Ltd, Basel) ;
Gossens, Christian (F. Hoffmann-La Roche Ltd, Basel) ;
Lindemann, Michael (F. Hoffmann-La Roche Ltd, Basel) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Objective To validate the smartphone sensor-based Draw a Shape Test - a part of the Floodlight Proof-of-Concept app for remotely assessing multiple sclerosis-related upper extremity impairment by tracing six different shapes. [...]
2023 - 10.1002/acn3.51705
Annals of Clinical and Translational Neurology, Vol. 10 Núm. 2 (2023) , p. 166-180
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5.
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14 p, 2.2 MB |
Associations of with clinico-radiological measures in a large population
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Sotirchos, Elias S. (Johns Hopkins University School of Medicine) ;
Fitzgerald, Kathryn (Johns Hopkins University School of Medicine) ;
Singh, Carol (Biogen) ;
Smith, Matthew D. (Johns Hopkins University School of Medicine) ;
Reyes-Mantilla, Maria (Johns Hopkins University School of Medicine) ;
Hersh, Carrie (Cleveland Clinic) ;
Hyland, Megan H. (University of Rochester Medical Center) ;
Canissario, Ryan (University of Rochester Medical Center) ;
Simmons, Sarah B. (Mellen Center, Neurological Institute, Cleveland Clinic) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Naismith, Robert (Washington University in St. Louis) ;
Qiao, Min (Washington University in St. Louis) ;
Krupp, Lauren B. (New York University) ;
Nicholas, Jacqueline A. (Riverside Methodist Hospital) ;
Akgün, Katja (University Clinic Carl-Gustav Carus) ;
Ziemssen, Tjalf (University Clinic Carl-Gustav Carus) ;
Rudick, Richard ((formerly) Biogen) ;
Fisher, Elizabeth (Biogen) ;
Bermel, Robert (Mellen Center, Neurological Institute, Cleveland Clinic) ;
Mowry, Ellen (Johns Hopkins University School of Medicine) ;
Calabresi, Peter A. (Johns Hopkins University School of Medicine) ;
Universitat Autònoma de Barcelona
Evaluation of serum neurofilament light chain (sNfL), measured using high-throughput assays on widely accessible platforms in large, real-world MS populations, is a critical step for sNfL to be utilized in clinical practice. [...]
2022 - 10.1002/acn3.51704
Annals of Clinical and Translational Neurology, Vol. 10 (november 2022) , p. 84-97
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6.
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8 p, 1.1 MB |
Accelerated long-term forgetting over three months in asymptomatic APOE ɛ4 carriers
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Tort-Merino, Adrià (Institute of Neurosciences. University of Barcelona) ;
Laine, Matti J. (Department of Psychology. Åbo Akademi University) ;
Valech, Natalia (Hospital Clínic i Provincial de Barcelona) ;
Olives, Jaume (Institute of Neurosciences. University of Barcelona) ;
León, María (Hospital Clínic i Provincial de Barcelona) ;
Ecay-Torres, Mirian (Centro de Investigación y Tecnología Agroalimentaria de Aragón) ;
Estanga, Ainara (Centro de Investigación y Tecnología Agroalimentaria de Aragón) ;
Martinez-Lage, Pablo (Centro de Investigación y Tecnología Agroalimentaria de Aragón) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rodríguez-Fornells, Antoni (Institució Catalana de Recerca i Estudis Avançats)
Accelerated long-term forgetting (ALF) refers to a rapid loss of information over days or weeks despite normal acquisition/encoding. Notwithstanding its potential relevance as a presymptomatic marker of cognitive dysfunction, no study has addressed the relationship between ALF and Alzheimer's disease (AD) biomarkers. [...]
2021 - 10.1002/acn3.51245
Annals of Clinical and Translational Neurology, Vol. 8 Núm. 2 (february 2021) , p. 477-484
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6 p, 1.6 MB |
Novel PLEKHG5 mutations in a patient with childhood-onset lower motor neuron disease
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Gonzalez-Quereda, L (Institut d'Investigació Biomèdica Sant Pau) ;
Pagola-Lorz, Inma (Instituto de Investigación Sanitaria de Navarra) ;
Fuentes Prior, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Bernal, Sara (Institut d'Investigació Biomèdica Sant Pau) ;
Rodriguez, María José (Institut d'Investigació Biomèdica Sant Pau) ;
Torné, L. (Neurology Department. Complejo Universitario de Navarra. IdisNa) ;
Salgado Garrido, J. (Instituto de Investigación Sanitaria de Navarra) ;
Gallano, Pia (Institut d'Investigació Biomèdica Sant Pau) ;
Jericó, Ivonne (Instituto de Investigación Sanitaria de Navarra)
The PLEKHG5 gene encodes a protein that activates the nuclear factor kappa B (NFκB) signaling pathway. Mutations in this gene have been associated with distal spinal muscular atrophy IV and intermediate axonal neuropathy C, both with an autosomal recessive mode of inheritance. [...]
2021 - 10.1002/acn3.51265
Annals of Clinical and Translational Neurology, Vol. 8 Núm. 1 (january 2021) , p. 294-299
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5 p, 1016.9 KB |
Interaction between sex and neurofilament light chain on brain structure and clinical severity in Huntington's disease
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Sampedro, Frederic (Institut d'Investigació Biomèdica Sant Pau) ;
Martinez-Horta, Saul (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez-Pérez, Jesús (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez-González, Rocío (Institut d'Investigació Biomèdica Sant Pau) ;
Horta, Andrea (Institut d'Investigació Biomèdica Sant Pau) ;
Campolongo, Antonia (Institut d'Investigació Biomèdica Sant Pau) ;
Aracil-Bolaños, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Gómez-Ansón, Beatriz (Institut d'Investigació Biomèdica Sant Pau) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Female Huntington's disease (HD) patients have consistently shown a faster clinical worsening than male, but the underlying mechanisms responsible for this observation remain unknown. Here, we describe how sex modifies the impact of neurodegeneration on brain atrophy and clinical severity in HD. [...]
2021 - 10.1002/acn3.51460
Annals of Clinical and Translational Neurology, Vol. 8 Núm. 12 (december 2021) , p. 2309-2313
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10 p, 758.5 KB |
Drug-refractory myasthenia gravis : Clinical characteristics, treatments, and outcome
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Cortés-Vicente, Elena (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Álvarez-Velasco, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Pla-Junca, Francesc (Instituto de Salud Carlos III) ;
Rojas-Garcia, Ricard (Institut d'Investigació Biomèdica Sant Pau) ;
Paradas, Carmen (Instituto de Biomedicina de Sevilla) ;
Sevilla, Teresa (Universitat de València. Departament de Medicina) ;
Casasnovas, Carlos (Hospital Universitari de Bellvitge) ;
Gómez-Caravaca, María Teresa (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Pardo, Julio (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Ramos-Fransi, Alba (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pelayo-Negro, Ana Lara (Universidad de Cantabria) ;
Gutiérrez-Gutiérrez, Gerardo (Universidad Europea de Madrid) ;
Turon-Sans, Janina (Universitat Autònoma de Barcelona. Departament de Medicina) ;
López de Munain, Adolfo (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Guerrero-Sola, Antonio (Hospital Clínico San Carlos (Madrid)) ;
Jericó, Ivonne (Instituto de Investigación Sanitaria de Navarra) ;
Martín, María Asunción (Complejo Asistencial Hospitalario de Burgos) ;
Mendoza, María Dolores (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Morís, Germán (Hospital Universitario Central de Asturias) ;
Vélez-Gómez, Beatriz (Universidad de Sevilla) ;
García-Sobrino, Tania (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Pascual-Goñi, Elba (Institut d'Investigació Biomèdica Sant Pau) ;
Reyes-Leiva, David (Institut d'Investigació Biomèdica Sant Pau) ;
Illa, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Gallardo, Eduard (Institut d'Investigació Biomèdica Sant Pau)
To describe the clinical characteristics and outcomes in patients with refractory myasthenia gravis (MG) and to determine the effectiveness and side effects of the drugs used for their treatment. This observational retrospective cross-sectional multicenter study was based on data from the Spanish MG Registry (NMD-ES). [...]
2022 - 10.1002/acn3.51492
Annals of Clinical and Translational Neurology, Vol. 9 Núm. 2 (january 2022) , p. 122-131
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17 p, 1023.4 KB |
Selective vulnerability to atrophy in sporadic Creutzfeldt-Jakob disease
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Younes, Kyan (University of California, San Francisco (UCSF)) ;
Rojas, Julio C. (University of California, San Francisco (UCSF)) ;
Wolf, Amy (University of California, San Francisco (UCSF)) ;
Sheng-Yang, Goh M. (University of California, San Francisco (UCSF)) ;
Paoletti, Matteo (IRCCS Mondino Foundation) ;
Toller, Gianina (University of California, San Francisco (UCSF)) ;
Caverzasi, Eduardo (University of California, San Francisco (UCSF)) ;
Mandelli, Maria Luisa (University of California, San Francisco (UCSF)) ;
Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Kramer, Joel H. (University of California, San Francisco (UCSF)) ;
Cobigo, Yann (University of California, San Francisco (UCSF)) ;
Miller, Bruce L. (University of California, San Francisco (UCSF)) ;
Rosen, Howard J. (University of California, San Francisco (UCSF)) ;
Geschwind, Michael D. (University of California, San Francisco (UCSF)) ;
Universitat Autònoma de Barcelona
Identification of brain regions susceptible to quantifiable atrophy in sporadic Creutzfeldt-Jakob disease (sCJD) should allow for improved understanding of disease pathophysiology and development of structural biomarkers that might be useful in future treatment trials. [...]
2021 - 10.1002/acn3.51290
Annals of Clinical and Translational Neurology, Vol. 8 (may 2021) , p. 1183-1199
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